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You Have Cancer

By Arthur Cote

As the doctor moved his fingers around the protruding mass on my neck, he stood back and looked in my eyes and told me to go across the street at that moment to get a biopsy done of the lump.  He said the last biopsy wasn’t conclusive. The urgency startled me, I left the office and went directly to the pathology lab.

One year earlier, I had gone to an ears nose and throat specialist. After a biopsy, I heard those wonderful words “its not cancerous”.   At a dentist appointment later in the week, an oral surgeon assured me not to worry about the lump in my neck. That it was related to the root canal I had had and it would go away. In fact the surgeon showed me he also had a lump from dental work he had done. I dodged a bullet that day.  So I relaxed and went on my way.

We took off from San Francisco international airport en route to Wilmington North Carolina to attend a wedding.

It was May. Beautiful weather.

We touched down, got our rental car and drove to our hotel to start our 2 week vacation.  My wife, Debbie, had to travel up to Canada for a few days on business while in NC, I would stay with a friend while she was away.

I was very excited to hit up a great burger place in town with my buddy Jim the first full day of our trip. This burger, found at PT’s Burgers, is one of the wonders of the world, with the most crispy and delicious french fries.  As we sat down to eat, my phone rang. It was my ENT doctor. He said calmly and without stopping, “Mr. Cote, unfortunately the biopsy came back positive. You have a Squamous Cell Carcinoma on your neck and it must come out immediately.!”

My lunch was over.

I sat for awhile, unable to speak, pick up my burger, or move.  It felt as if  sound itself had ceased, that I sat in a vacuum.  My legs trembled a bit.  I asked the caller if I’d be alive in a year.  The doctor was silent for a few seconds, then told me he couldn’t say until he saw the tumor.  I asked if I should return to California immediately, he demanded I enjoy my vacation.  I was in for a rough course when I returned home.

Returning to Jims’ office, I sat at a desk trying to work.  It was an impossible task. All I could think of was how much trouble I was in. After about an hour, Jim suggested we leave the office for the day. We picked up a bottle of Tequila, and headed to his house for an evening of forgetting.  Thankfully, the night passed.

Morning had come, cancer was my first thought. That I may be dying was the second. I was down right scared out of my wits. But I was able to get some work done. Debbie had called the evening before and told me the doctor had called her too, but she hadn’t spoken with him. I told her the news.  I eagerly looked forward to her returning to Wilmington.

We partied for the remaining days as “cancer” kept pushing itself into my consciousness.  As we drove to the airport on our way back home, we spoke about what we were going back home to. Surgery had been scheduled for Jun 2nd, a few days after our return.

June 2nd arrives.

Hospitals have always been a place of refuge to me since working as an EMT in NYC whilst in my twenties and in school. I had complete confidence in my doctors, and in the hospital, UCSF Medical Center in San Francisco Mount Zion.  While I was terrified as they wheeled me into the operating room, and strapped me down on the table, I wasn’t sure I w
ould come out of the surgery in tact, but I knew I was in good hands. My surgeon, a top guy in head and neck cancer, told me point blank how serious the surgery was.

As I woke up in recovery and saw Debbie’s beautiful face, I knew I had made it. But when I saw her expression, I knew it was serious.  When my surgeon came in to check on his handiwork, Deb had sort of confirmed to him that my prognosis was good. That I would just “Need some radiation and then I’d be fine.”  He shot back asking who had given her that news. That in fact, the tumor was stage 4. It was very serious and offering a prognosis was to early.  The biopsy and planned MRI would tell the story.  My next step was to recover from surgery and see a radiation oncologist.

The first night in my room. I suddenly felt a gushing of pain all over my head and neck.  I called the nurse to request more pain meds. She informed me I had gotten my quota of tylenol for the day therefore I would have to wait for tomorrow! I asked her if she was kidding, that I had had surgery earlier today. She wasn’t.  I sat up all night in screaming agony.

The next morning I told my surgeon what happened. He went out to the nursing station and changed the order from PRN (as needed) to every 4 hours.

Entering the exam room I glanced up at the signage over the room: oncology consult. It slammed me in the face as if I ran into the wall.

The doctor introduced herself as a radiation oncologist. Her second was chief resident. As Dr Kam moved in front of me, she rattled off a check list: MRI, Radiation, then Chemo. When I asked her if I would be in need of Chemotherapy, she snapped back we needed to wait for the surgical biopsy to return, but she was just setting things up as she saw them. This doctor was very matter of fact. I could tell by her bedside demeanor they didn’t hold high hopes for my survival. I presented as a very ill young guy at 53, in relatively excellent shape – running 3 miles a day.

As the exam progressed, Dr. Kam pressed their must be a primary tumor somewhere in my body and that it has to be discovered and treated. Result? An MRI, and a Pet Scan. She also scheduled me for radiation therapy: 33 days 5 days a week.

While the MRI and Pet Scan was negative, no additional tumors were found, Dr. Kam pushed hard for me to begin radiation. She informed me I would most likely have dental problems resulting from the treatment, moderate hair loss, and other bothersome side effects up to and including getting a feeding tube installed in your nasal cavity.  I told her I would not have a feeding tube, and that I would make it out on my own two feet in the end. She politely smiled.

Day 1 Radiation assessment exam.

I walked into the radiation oncology unit with great trepidation.  As I sat down, Dr. Kam explained how I would need to be measured for a mask that aids in keeping the head still during treatment (right).

As the system shoots rads at you in the general direction of where the tumor lived, ones whole body has to be screwed down onto a table that based on computer commands, moves to required positions for deliverying treatment.

The measurements were taken, I was given my treatment start date, and went on my way. I recall feeling like my life was in its waning days, that all this action by doctors on my behalf was an attempt. That in fact my prognosis was on shaky ground.

The pain got worse as I healed from the surgery and started radiation treatment. My sons strongly suggested I try cannabis to ease the pain and to ease my high anxiety over beginning treatment. I tried it and was amazed that I was able to sleep for the first time through the night.  Cannabis saved me.

First Day Of Radiation Treatment

I arrived right on time for my first appointment, thinking I can get in and out as fast as possible to get the hell away from the hospital.

Upon entering the waiting room in the basement of the hospital (UCSF), I was met by a fellow who took me around to show me the “ropes”;  first change into hospital garb – opened-in-the-back gown, and surgical pants.

Entering the patient waiting area, I was shocked to find it crowded with what looked to me like the walking wounded. Some looked worse than others. The room was hot, very uncomfortable.  Watching the waiting patients gave me a sick feeling in the pit of my stomach. A man sitting next to me told me he had prostate cancer and was almost done with his treatment; he looked like a corpse that was unaware of his death.

When the technician called my name I was relieved to get the hell out of that room, only realizing I’d be sitting in that room at 3:20 every day for 33 visits! Yikes.

I entered the treatment room. The staff placed me on the table, nailed down my face mask using clips that connected my head to the table. As I laid there waiting, I thought “What happens if there is an earthquake? I’m screwed, thats what!” A warm blanket was placed on me, and I was told the treatment would start once the techs left the room.

My mind was racing. Panic set in. What the hell was happening here? Why was this happening to me? Then the machine whirred to action and the treatment started.

Each day, the treatment lasted 10 minutes. Each day I loathed more and more to go to the hospital for treatment.

Before the first full week of treatment had concluded, it was Friday, I woke up feeling very ill. Vomiting, bad stomach cramps, dizzyness. Feeling really ill and in bad pain.

The doctor said it most likely was the flu, and that I should drink lots of fluids.  After 2 days, I ended up in the emergency room.

The ER physician examined me and called in internal medicine consult. My sodium level was dropping dangerously low, and they didn’t know why. They admitted me.

Endocrinology consult came to my room the following morning. She explained the suspected culprit was my adrenal glands. That perhaps they weren’t working fully if at all, and that would cause a drop in sodium level. Dr. Bellgo ordered an MRI of my brain, and blood work.

Dr. Bellgo delivered the results.  Somehow along the way, my adrenal glands were “blown out”, or as she put it, atrophied.  I asked how this could’ve happened. She mentioned she had looked at my pre-op labs and that my sodium levels and other metrics were normal. So it happened sometimes from the tumor surgery forward.

No doctor would address what exactly happened. When I mentioned it to my surgeon, he shrugged. He wouldn’t address it. No one would. Until this day.

To stay alive I need to take 2 steroids replacement therapy.  This continues 2 years later.

After I left the hospital, my doctor was VERY anxious for me to start up radiation again, so it was rescheduled. And I went through each day of treatment feeling like a hot dog in a microwave oven.  My body ached, and burned from the results of surgery, and now new pain from the radiation treatment.

I concluded the radiation treatment, and am left with chronic neuropathic pain, and muscular pain on my right side where the tumor was.  If I didn’t have access to cannabis, I would be in big trouble. Cannabis relaxed me enough to be transfixed to a table for radiation treatment, and it relaxes me every night, blocking the steroids enough to let me get a good nights sleep.

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Patrick Goggin overview of AB 2552

AB 2552: Misguided From Every Angle by Patrick Goggin

Assembly member Norma Torres (D-CA) introduced AB 2552 earlier this legislative session. The bill would effectively criminalize driving with any detectible level of THC in the system. None. The ramifications of such a bill becoming law are tremendous indeed.

Never mind that government testing is unreliable – the lack of minimum levels would not only criminalize medical cannabis patients but the millions among us who consume healthy hemp foods. Other states like Colorado are considering legislation similar to Torres’ and together they have sparked a debate over what minimum levels should be reasonably established to recognize medical cannabis patients and hemp food consumers.

Torres’ short-sited legislation and its ilk should be emphatically rejected by the respective state legislatures. Alternatively, the legislatures should work with cannabis industry leaders to establish reasonable standards if they want enact to measured laws to minimize driving under the influence.

Quality Assurance Priorities for the Medical Marijuana Industry by Robert W. Martin, Ph. D.

Quality Assurance Priorities for the Medical Marijuana Industry

The Four Pillars of Quality; Product Safety, Truth in Labeling, Tamper evident Packaging, and Dosage

R.W. Martin, Ph. D.

Background

Since its beginnings at the turn of this century, California Cannabis Testing Laboratories have been focused primarily on cannabinoid testing.  The motivation for most users or dispensaries to use laboratories has been driven by the eagerness to find more potent strains and understand the potency of extant strains.  The discovery of more cannabinoids and the promising data surrounding the efficacy of CBD in particular has fueled even more interest in the further understanding of these cannabinoids.

Terpenoids (aromatic compounds associated with plants) have also been gaining interest of many of the Cannabis Testing Laboratories, at least within California, even though these compounds exist at almost trace amounts.  These terpenes are thought by some to be related to specific symptomatic issues relating to patient care. Others  believe that the terpenes enhance aroma therapy and taste of fresh products during consumption.  Preliminary investigations are underway in several laboratories to further identify and quantify these compounds in the various strains currently being commercialized.

To date, little emphasis has been placed upon the three pillars of Quality Assurance, namely 1) product safety, 2) labeling, and  3) tamper evident packaging that are usually considered major quality components in most consumer or patient-based delivery systems.  Dosage is added here as the forth pillar as it becomes very important to understand the strength of a certain medicine delivery system.  This emphasis is, in part, due to the fact that the experience base of most California Cannabis laboratories is primarily chemistry.  Hence, these chemist led laboratories play to their strength, and offer really top notch, very impressive chemical analyses to their patients.  There are labs that offer a wide range of cannabinoid and terpenoid profiling because they have the background to do so.  However, these cannabinoid and terpenoid analyses don’t begin to address the quality needs of the industry.  The following is a document that seeks to share existing concepts and principles of Quality Assurance and how they may relate to the medical marijuana industry in California.

1)    Product Safety

First and foremost in any Quality Assurance program is the concept of product safety.   In the medical marijuana industry,” products” refer to (1) the fresh prepared flowers as well as, (2) food processed with the infusion of cannabinoids:

1)     Prepared Flowers

It has been shown through testing that prepared flowers can yield very high numbers of bacteria and mold spores.  These high numbers, in most cases, indicate, for bacteria: poor handling or hygiene during processing and drying; and for mold the presence of a fungal species pathogenic or saprophytic on the flower.  High bacterial spore counts also increase the probability for the presence of human pathogens.  Pathogens such as Pseudomonas spp. have been identified on flowers grown and processed in California (CW Analytical file data).  Aspergillus has also been reported, a pathogen that produces Aflatoxin, an exocellular excretion known to be toxic to all mammals.

It has also been shown that residues of pesticides and fungicides can be present on prepared flowers, especially those grown indoors. These residues are known to sequester in human tissues and are implicated in a wide range of physiological disorders.

The minimum testing for QA approval of a flowered product=Residue Testing, Bacterial Screening, and Yeast and Mold Screening with potency testing optional (AOAC 986.33, 991.14, and 997.02).  Potency will be discussed in the Dosage Section below.

2)     Food processed with infusion of cannabinoids

Cannabinoid infused food should be tested similarly to food processed and distributed in existing food channelsThe minimum tests for acceptable Quality Assurance for edible food products infused with cannabinoids are= Bacterial Screening and Yeast and Mold Screening. (AOAC 986.33, 991.14, and 997.02) Potency will be discussed in the Dosage Section below.

2)    Product Labeling

The Sherman Food, Drug, and Cosmetic Law of 2008 clearly states that all food products be labeled accurately and consistently with standardized descriptions and labels (NLEA, 1991, Sherman Food and Cosmetic Act, 2008). This should be considered appropriate for both (1) prepared flowers as well as (2) food products infused with cannabinoids:

1)     Prepared flowers

Dried flowers should be tested, bagged and sealed prior to dispensing to patients. Vacuum, nitrogen flush and hermetic sealing are all options currently available. Efficient bagging will maintain freshness and guard against further contamination. Labels indicating date of bagging, level of testing (cleanliness), and potency (if desired) should be prominently displayed on each bag.

2)     Food processed with infusion of cannabinoids

All food products must be labeled using the 1997 convention adopted by the NLEA*. That is, all labels must include mandatory reporting of nutritional values based on serving size.  These values include calories, fat, protein, carbohydrate, cholesterol, sodium, Trans fat, fiber, sugar, with vitamins A and C, and iron.  Further, all potential allergens must be clearly identified and labeled to guard against accidental ingestion.  An ingredient statement in order of preponderance is also mandatory. Labels may be based on either calculated data or actual nutrition testing. Minimum requirement for label compliance= NLEA convention food label and accurate ingredient statement.

*= It is understood that some municipalities are uncomfortable with current labeling doctrine and that they seek to make packaging as different as possible to guard against mistakes with non-patients. CW Analytical strongly suggests that nutritional labels be offered at point of sale as information sheets or addendum added to the purchase of an edible in these situations.

 3)    Tamper Evident Packaging

 Tamper evident packaging should be required for all medical marijuana products whether fresh or processed.  The accidental exposure of non-patients to these medications should be taken very seriously and barriers such as these should be mandatory.

The US Code of Federal Regulations (21 CFR 211.132) defines OTC Drug tamper evidence as = – Tamper-evident packaging requirements for over-the-counter (OTC) human drug products:

“A tamper-evident package is one having one or more indicators or barriers to entry which, if breached or missing, can reasonably be expected to provide visible evidence to consumers that tampering have occurred. To reduce the likelihood of successful tampering and to increase the likelihood that consumers will discover if a product has been tampered with, the package is required to be distinctive by design or by the use of one or more indicators or barriers to entry that employ an identifying characteristic (e.g., a pattern, name, registered trademark, logo, or picture).”

Minimum requirement for medical marijuana industry = tamper evident packaging meeting requirements listed above

4)    Dosage

 Potency ranks fourth on the Quality Assurance priority as a nice to know datum point in one aspect and a need to know in another.  The potency of prepared flowers and concentrates is a nice to know in terms of commercial value and psychoactive potential but becomes a need to know datum point when calculating the potency for a dosage calculation in edible form*. Whether it be prepared flower or concentrate, the accurate depiction of cannabinoid levels are necessary for dosage calculations and serving size coordination to the patient. Minimum cannabinoid testing should include THC, CBD, and CBN values.

*It should be noted that there is currently no known dosage widely accepted for this industry.  Patient response to various dosages is very diverse and should be considered as a case by case basis.  CW Analytical recommends 20-25 mg as a standard single dose of THC.

 These opinions are respectfully submitted and based upon 30+ years within the food industry serving as a Director of Research and Quality Assurance in large multinational food corporations.  This document is intended soley for educational purposes and should be considered preliminary in scope and a precursor to formal ISO and HACCP program development. All questions should be directed to:

Dr. Robert Martin

Director, CW Analytical Laboratories

Oakland California

925-719-0463

robert@cwanalytical.com

 

Evangelical Pat Robertson Supports Legalization!

Pat Robertson tells the New York Times “I really believe we should treat marijuana the way we treat beverage alcohol,” Mr. Robertson said in an interview on Wednesday. “I’ve never used marijuana and I don’t intend to, but it’s just one of those things that I think: this war on drugs just hasn’t succeeded.”

Robertson argues that legalizing cannabis is a way to bring down soaring rates of incarceration and reduce the social and financial costs. His closing statement in the article is “I just want to be on the right side,” he said. “And I think on this one, I’m on the right side.”

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Cannabis Prohibition: Follow The Money

People are waking up to the REALITY of hemp and the corporate control of our lawmakers that keeps this resource illegal. Here is an example of the information circulating on the web.